Beyond The Androgen Receptor: The Role Of Growth Hormone Secretagogues In The Modern Management Of Body Composition In Hypogonadal Males
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Deepankar K Sinha
Adithya Balasubramanian
Alexander J Tatem
Jorge Rivera-Mirabal
Justin Yu
Jason Kovac
Alexander W Pastuszak
Larry I Lipshultz
Abstract
Hypogonadism in men is traditionally managed with testosterone replacement therapy (TRT) to restore libido, energy, and muscle mass. However, TRT alone may not fully address alterations in body composition, particularly the decline in lean body mass and increase in visceral adiposity that accompany aging and
cjc 1295 + ipamorelin side effects chronic disease. Growth hormone secretagogues (GHSs), which stimulate endogenous growth hormone (GH) release, have emerged as a complementary strategy to improve muscle hypertrophy, reduce fat mass, and enhance metabolic health in hypogonadal males. This review examines the pharmacodynamics of key GHS agents—sermone…
