CJC 1295 with ipamorelin is a popular peptide stack used by bodybuilders and anti‑aging enthusiasts to boost growth hormone release, increase lean muscle mass, enhance recovery, and potentially improve skin elasticity and joint health. The combination delivers synergistic effects because each peptide targets the pituitary gland in slightly different ways, resulting in a more robust stimulation of natural growth hormone secretion than either agent alone.
Ipamorelin + CJC 1295 Stack: The Dynamic Duo
When ipamorelin and CJC 1295 are taken together, they form what many practitioners call "the dynamic duo." Ipamorelin is a selective growth hormone‑releasing peptide (GHRP) that mimics ghrelin’s action on the pituitary, stimulating the release of growth hormone with minimal stimulation of other hormones such as cortisol or prolactin. CJC 1295, on the other hand, is a growth hormone‑releasing hormone analogue (GHRH) that binds to the GHRH receptors in the pituitary and prolongs the release of growth hormone by preventing its rapid degradation. By combining a GHRP with a GHRH analogue, the stack achieves higher peaks of growth hormone while maintaining a steady baseline level. Users report increased muscle mass, faster recovery from workouts, improved sleep quality, and a noticeable reduction in body fat.
What is Ipamorelin?
Ipamorelin is a pentapeptide (five amino acids long) that was originally developed to treat growth hormone deficiency. Its structure closely resembles ghrelin but with a higher selectivity for the growth hormone secretagogue receptor (GHS‑R). Because of this selectivity, ipamorelin induces robust growth hormone secretion without significantly elevating appetite or cortisol levels. In clinical studies, ipamorelin has shown promising results in improving bone density, enhancing wound healing, and supporting muscle regeneration.
The peptide is usually administered via subcutaneous injection, with dosing protocols ranging from 100
