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Tesamorelin Vs Ipamorelin: Key Differences, Benefits, And Uses


Tesamorelin vs Ipamorelin: What are the Key Differences, Benefits, and Uses

The comparison between tesamorelin and ipamorelin focuses on their distinct mechanisms, therapeutic roles, safety profiles, and practical considerations for users.



What Are Tesamorelin and Ipamorelin?

Both compounds belong to the peptide class but serve different purposes. Tesamorelin is a synthetic growth hormone‑releasing factor (GHRF) that stimulates endogenous growth hormone production, primarily used in metabolic disorders. Ipamorelin is a selective growth hormone secretagogue (GHS) that directly promotes growth hormone release without significant prolactin or cortisol effects.



Tesamorelin Overview




FDA approved for reducing excess abdominal fat in HIV‑associated lipodystrophy.


Administered subcutaneously, typically 2 mg once daily.


Enhances insulin sensitivity and improves lipid profiles.


Long‑term use requires monitoring of growth hormone levels to avoid acromegalic changes.



Ipamorelin Overview



Not FDA approved; used off‑label for body composition, anti‑aging, and athletic performance.


Delivered subcutaneously or intramuscularly, usually 100–200